Supplemental High Flow Oxygen to Reduce Infections in Obese Gynecological Cancer Patients

Recruiting now · Not applicable

Conditions studied: Supplemental Oxygen, Gynecological Cancer, Surgical Site Infections

In brief

The incidence of surgical-site infection (SSI) and complications related to wound healing reaches 10-20% of gynecological cancer patients. Each complication may dramatically prolong the hospitalization period and increase the economic burden of hospital care. Appropriate wound care and tissue oxygenation are of special importance for wound healing. Assuming adequate perfusion, the easiest, safest, and most effective way to improve tissue oxygenation is to increase the fraction of inspired oxygen. However, there is considerable controversy as to whether supplemental oxygen actually reduces SSI and healing-related complications as to date, there is absence of relevant data.

Key facts

Study ID

NCT06780813

Run by

National and Kapodistrian University of Athens

People needed

400

Starts

2025-01-10

Expected to finish

2026-05-01

Last updated by the study team

2025-01-17

Who can join

Age: 18 and older, up to 85. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Obese (BMI>30kg/m2) gynecological cancer patients
• Optimized preoperative CBC values (hemoglobin >11g/dl, WBC 4.000-11.000 X 109/L, platelets 150,000 to 400,000 X 109/L)
• In the case of neoadjuvant therapy an interval longer than three weeks between the last cycle and the operation

You may not qualify if…

• Active immunosuppresion
• Preexisting infection of the abdominal wall
• Preexisting sepsis

Where it is running

• First department of Obstetrics and Gynecology — Athens, Greece (enrolling)

Full record on ClinicalTrials.gov

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