Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients

Recruiting now · Phase 2

Conditions studied: Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury

In brief

This clinical trial aims to determine the effects of a 6-day low-dose methylprednisolone course on pain, nausea, and total opioid consumption in patients undergoing foot and ankle surgeries. The secondary objective of the study is to determine and monitor the effects of the course on complications following surgery and patient-reported outcomes

Key facts

Study ID

NCT06780202

Run by

Emory University

People needed

180

Starts

2025-01-27

Expected to finish

2027-12-01

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Emory Orthopedic patients undergoing foot and ankle surgery

You may not qualify if…

• Concurrent or significant injuries to other bones or organs
• Local infections
• History of alcohol or medical abuse, including prior opioid abuse
• Smoking
• History of severe heart disease, renal failure, liver dysfunction, active peptic ulcer disease, diabetes, rheumatoid arthritis, neurological or psychiatric diseases that could influence pain perception
• Pre-existing immune suppression
• Those deemed possibly non-compliant by the study team and,
• All vulnerable populations (those unable to give consent, juveniles, pregnant women, prisoners, cognitively impaired and non-English speaking).

Where it is running

• Emory Musculoskeletal Institute, Emory Orthopaedics & Spine Center — Atlanta, Georgia, United States (enrolling)
• Emory Sports Medicine Complex and Emory Orthopaedics and Spine Center — Johns Creek, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

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