Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Recruiting now
Conditions studied: Pregnancy Complications, Pre-Eclampsia, Growth Retardation, Intrauterine
In brief
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality. It is essential to understand the cellular and molecular mechanisms of dysfunctions at the vascular-placental interface so that systemic vascular risk can be characterized and, ultimately, screened for, on the basis of new markers (targeted preventive management). Deregulated autophagy could be the starting point for cell death by apoptosis or necrosis leading to complications. The pathophysiological mechanisms involved in trophoblast apoptosis are incompletely described. This project follows on from the GrossAuTop-1 study, which investigated the intra- and inter-individual variability of autophagy and apoptosis activities in women during pregnancy. The aim of this project is to study autophagy and apoptosis activities specifically in women developing a placental vascular complication during pregnancy.
Key facts
- Study ID
- NCT06779916
- Run by
- Centre Hospitalier Universitaire de Nīmes
- People needed
- 50
- Starts
- 2025-05-02
- Expected to finish
- 2029-05-01
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Pregnant women developing a placental vascular complication (preeclampsia and/or intrauterine growth retardation), hospitalized and delivering at Nimes University Hospital.
- Pregnant woman with free and informed consent.
- Pregnant woman affiliated with and/or benefiting from a health insurance scheme.
You may not qualify if…
- Multiple pregnancy.
- Presence of hypertension and/or proteinuria prior to pregnancy.
- Participant in an interventional drug study.
- Persons in a period of exclusion determined by another study.
- Persons under court protection, guardianship or curatorship.
- Persons unable to give consent.
- Persons for whom it is impossible to give informed information.
Where it is running
- Nimes University Hospital — Nîmes, France (enrolling)
Full record on ClinicalTrials.gov
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