Hybrid Arc Palliative Radiation Therapy (HART): A Single Arm Phase II Trial

Recruiting now · Phase 2

Conditions studied: Palliative Radiotherapy, Metastatic Cancer (Different Solid Tumour Types)

In brief

This is a prospective single-center single-arm Phase II trial of HART for patients with metastatic cancer. The primary objective is to assess the incidence of acute GI toxicity following HART. PRO-CTCAE GI scores observed in the study patients will be compared to historical rates. Secondary outcomes include measuring changes in health-related quality of life, esophageal quality of life, toxicity, dosimetric outcomes, and pain.

Key facts

Study ID: NCT06778408
Run by: University of Vermont Medical Center
People needed: 103
Starts: 2025-04-28
Expected to finish: 2028-03-01
Last updated by the study team: 2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Histological confirmation of cancer with radiographic (CT, MRI or PET) evidence of metastatic disease
Palliative radiotherapy indicated for bone or soft tissue metastases, or primary targets, located in the thorax, abdomen, or pelvis as part of their standard of care treatment plan
Age ≥ 18 years.
Women of child-bearing potential and men must agree to use adequate contraception prior to study entry, for the duration of study participation, and for 90 days following completion of therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
In lieu of a pregnancy test, participants may sign the Pregnancy Attestation Form, a standard form routinely used in clinical practice at UVMCC.
Recommended methods of birth control are:
The consistent use of an approved hormonal contraception (birth control pill/patches, rings), An intrauterine device (IUD), Contraceptive injection (Depo-Provera), Double barrier methods (Diaphragm with spermicidal gel or condoms with contraceptive foam), Sexual abstinence (no sexual intercourse) or Sterilization.
Men must agree to use a condom and not father a child or donate sperm for the duration of the study and for 90 days after completion of therapy.
A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
Has not undergone a hysterectomy or bilateral oophorectomy; or
Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
Ability to understand and the willingness to sign a written informed consent.

You may not qualify if…

Patients receiving any other investigational agents or concurrent cytotoxic chemotherapy
Patients who are pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.
Serious medical comorbidities, which in the opinion of the radiation oncologist preclude the delivery of RT

Where it is running

University of Vermont Medical Center — Burlington, Vermont, United States (enrolling)

Full record on ClinicalTrials.gov

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