ThRombectomy In Mild Ischemic Stroke With a Visible Intracranial veSsel Occlusion

Completed

Conditions studied: Stroke

In brief

The purpose of TRIMIS is to study how a medical procedure by the name of endovascular therapy compares to medical treatment alone in patients with mild stroke and a blood vessel occlusion in the brain

Key facts

Study ID

NCT06778226

Run by

University of Miami

People needed

4827

Starts

2018-01-01

Expected to finish

2026-04-22

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute ischemic stroke in an adult patient (18 years of age or older).
• Onset (Last Seen Normal) time to treatment time <24 hours or unknown Last Seen Normal in whom Endovascular Therapy could be considered per local radiographic guidelines.
• Mild stroke defined as an NIH Stroke Scale ≤ 5 at the time of treatment decision.
• a. Patients with NIH Stroke Scale=0 can be included in the study if they have relevant abnormalities on neurological exam.
• An acute intracranial vessel occlusion (Intracranial Internal Carotid Artery terminus (T or L clot), Middle Cerebral Artery (M1, M2, M3/beyond), Anterior Cerebral Artery (A1, A2, A3), V4, Basilar, Posterior Cerebral Artery) defined by non-invasive acute imaging (Computed Tomography, angiography (Computed Tomography Angiography) or Magnetic Resonance angiography (MRA)) that is neurologically relevant to the presenting symptoms and signs.

You may not qualify if…

• Stroke symptoms due to another non-ischemic acute neurological condition such as seizure with Post-ictal Todd's paralysis or focal neurological signs due to severe hypo- or hyperglycemia.
• Hyperdensity on Non-contrast Computed Tomography consistent with intracranial hemorrhage. Any clinical suspicion of any intracranial hemorrhage even in the absence of visible blood on baseline brain imaging.
• Large acute stroke >1/3 Middle Cerebral Artery territory or Alberta Stroke Programme Early CT score (ASPECTS<6 or established frank hypodensity relevant to the presenting acute stroke already visible on baseline CT scan.
• Findings on acute CT or MRI to suggest that the
• Patient has a severe or fatal or disabling illness that will impact decision regarding acute reperfusion therapies.
• Pregnancy.
• Clinical history, past imaging and clinical judgment suggest that the intracranial occlusion is chronic.
• Stroke occurred as an inpatient.
• Inclusion into any randomized control trials.

Where it is running

• University of Miami — Miami, Florida, United States
• Boston Medical Center — Boston, Massachusetts, United States
• Brown University — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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