COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
Recruiting now
Conditions studied: Pain, Genetic Change, Children, Only
In brief
The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries. The main question\[s\] it aims to answer \[is\]: Do OPRM1 and COMT SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries? Participants will be assessed for their pain scores, sedation level, the amount of postoperative analgesics received, duration of their stay in the post-anesthesia care unit, and toxicity.
Key facts
- Study ID
- NCT06777875
- Run by
- American University of Beirut Medical Center
- People needed
- 200
- Starts
- 2025-03-10
- Expected to finish
- 2027-01-13
- Last updated by the study team
- 2025-03-18
Who can join
Age: 8 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All children 8 years to 18 years
- Undergoing orthopedic, abdominal, thoracic, and plastic surgeries
- American Society of Anesthesiologists classification (ASA) I-II-III
You may not qualify if…
- Children with schizoid personality disorders, phobias, and anxiety
- Patients with neuropathic pain associated with surgeries requiring surgical treatment.
- Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse.
- American Society of Anesthesiologists classification (ASA) ≥IV
- All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.
Where it is running
- Roland Kaddoum — Beirut, Lebanon (enrolling)
Full record on ClinicalTrials.gov
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