Endodontic Microsurgery

Starting soon · Phase 4

Conditions studied: Apical Periodontitis

In brief

Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched. Whether it is able to reduce post-op pain or if it improves success rate in endodontic microsurgery is not well known. It is also not well known if it will be able to increase the rate of healing. This study will evaluate the success of endodontic microsurgery with and without PRF.

Key facts

Study ID

NCT06776289

Run by

Mark Schachman

People needed

20

Starts

2026-10-01

Expected to finish

2027-08-01

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Maxillary or Mandibular Anterior teeth and premolars #4-13 and #20-29 with a history of failing RCT and a periapical radiolucency will be accepted

You may not qualify if…

• Patients with vertical root fractures
• Patients with non-restorable teeth
• Patients with class 3 mobility
• Pregnant
• Smoker
• Systematic disease contraindicating surgery

Where it is running

• University of Kentucky College of Dentistry Endodontics Division — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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