Physical Activity and Insulin Sensitivity Dynamics

Recruiting now · Not applicable

Conditions studied: Insulin Sensitivity

In brief

The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. Furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity. This will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.

Key facts

Study ID

NCT06776094

Run by

University of Copenhagen

People needed

8

Starts

2025-05-05

Expected to finish

2027-01-01

Last updated by the study team

2025-12-02

Who can join

Age: 22 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy individuals (no known diseases)
• No use of medication
• Non-smokers
• Male
• Aged 22-35 years
• Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg
• BMI between 28 and 35

You may not qualify if…

• Women
• Failure to meet all inclusion criteria
• Physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week
• Acute illness within 2 weeks prior to the study days
• Use of recreational drugs within 2 weeks prior to the study days

Where it is running

• University of Copenhagen, August Krogh Section for Human and Molecular Physiology — Copenhagen, Denmark (enrolling)

Full record on ClinicalTrials.gov

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