Endometrioma Sclerotherapy and Ovarian Preservation

Recruiting now · Not applicable

Conditions studied: Endometrioma

In brief

A randomised controlled trial assessing ovarian reserve after laparoscopic ethanol sclerotherapy of ovarian endometrioma compared to standard treatment of surgical excision of endometrioma. Secondary outcomes will include endometrioma recurrence, symptomatology and inflammatory environment.

Key facts

Study ID

NCT06775769

Run by

Chelsea and Westminster NHS Foundation Trust

People needed

60

Starts

2025-02-21

Expected to finish

2027-12-31

Last updated by the study team

2025-11-25

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female (XX genotype, assigned female at birth)
• Age 18-40
• Finding of suspected uni- or bi-lateral ovarian endometrioma(ta) of ≥ 2cm on TVUSS and/or pelvic MRI scan (TVUSS, a uni- or multi-locular ovarian cystic lesion with low level echoes and diffuse homogeneous ground glass appearance; MRI any of, ovarian lesion hyperintense T1 without loss of signal on T1 fat-suppressed images, hypointense T2 exhibiting shading sign and/or T2 dark spot sign, variable restricted diffusion on DWI)
• Appropriate to be listed for laparoscopic excision of endometrioma (Endometrioma ≥2cm, pain symptoms attributable to endometriosis where medical management is unsuccessful or unacceptable to the patient, to facilitate ART)

You may not qualify if…

• Postmenopausal status
• Suspicion of malignancy
• Unable to undergo TVUSS
• Declines to take part in the study
• Unable to understand verbal or written information in English
• Lack of capacity to consent at the point of recruitment
• Known safeguarding issues

Where it is running

• Chelsea and Westminster NHS Foundation Trust — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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