Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)

Recruiting now · Not applicable

Conditions studied: SARS CoV-2, Kawasaki Disease, Retrovirus Infection

In brief

Human Endogenous Retroviruses (HERVs) are ancient sequences that became integrated into our DNA during evolutionary processes. The significance of their presence in DNA is still being studied, but HERVs appear to be involved in the regulation of the immune response. The gut microbiota is the set of microorganisms that physiologically colonize the gastrointestinal tract. Progressively increasing attention is being paid to the gut microbiota and its potential role in diseases of various kinds. In particular, it has recently been shown how abnormalities in the microbiota can affect immune regulation by determining the occurrence of certain diseases. One objective of the study is to evaluate whether there is an association between the expression of HERVs and clinical manifestations in pediatric age in patients with various diseases such as Kawasaki Disease, IgA Vasculitis/Schonlein-Henoch's Purpura, SARS-CoV-2 infection, or, finally, febrile virosis. Another objective of the study is to evaluate whether there is an association between the presence of particular types of bacteria in the gut microbiota and clinical manifestations in pediatric age in patients with Kawasaki Disease, IgA Vasculitis/Schonlein-Henoch purpura, SARS-CoV-2 infection or febrile virosis. The results from this may open new perspectives for both the care and therapeutic management of children with these diseases.

Key facts

Study ID

NCT06775457

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

120

Starts

2021-06-10

Expected to finish

2025-12-31

Last updated by the study team

2025-01-15

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pediatric patients, newly diagnosed with Kawasaki disease
• Pediatric patients, newly diagnosed with Vasculitis
• Pediatric patients, newly diagnosed with SARS-CoV-2 infection
• Pediatric patients, newly diagnosed with febrile virosis
• Pediatric patients with inflammatory diseases with systemic involvement

You may not qualify if…

• None

Where it is running

• Ospedale Ramazzini di Carpi, Azienda USL di Modena UO Pediatria — Carpi, Modena, Italy (enrolling)
• IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Pediatria d'Urgenza, Pronto Soccorso e Osservazione Breve ed Intensiva — Bologna, Italy (enrolling)
• Azienda Ospedaliera-Universitaria di Modena — Modena, Italy (enrolling)
• IRCCS Ospedale Pediatrico Bambino Gesù UOC Pediatria Generale — Roma, Italy (enrolling)
• Ospedale Regina Margherita, Torino, UO Reumatologia Pediatrica — Torino, Italy (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.