SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome

Recruiting now

Conditions studied: Respiratory Distress Syndrome (RDS), Respiratory Failure

In brief

The Acute Respiratory Distress Syndrome (ARDS) is a systemic syndrome characterized by severe respiratory failure, inflammation, loss of aerated tissue and high mortality. Recently, significant efforts have been made to phenotype ARDS patients through a wide range of new biomarkers and imaging indices with the goal of developing personalized treatments based on patient's biophenotypization. Recent literature demonstrates, both in vitro and in vivo but not yet in ARDS patients, that the serine protease inhibitor(SERPIN)-B3 plays a crucial role in the pathological mechanism of pulmonary fibrogenesis, and, similarly, protease-activated receptors(PAR2) is highly involved in this aberrant inflammatory response. Consequently, studying the expression of SERPINB3 (including SCCA-PD polymorphism) and PAR2, in association with a detailed clinical and biomolecular phenotypization, could allow new insights into the pathophysiological mechanisms of lung injury during ARDS.

Key facts

Study ID

NCT06774534

Run by

University of Padova

People needed

40

Starts

2025-02-28

Expected to finish

2030-12-31

Last updated by the study team

2025-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ARDS DIAGNOSIS
• IMV

You may not qualify if…

• Age under 18 years
• Pregnancy status
• Lack of consent to participate in the study
• Contraindications to fiberoptic bronchoscopy and/or BAL (bronchoalveolar lavage)
• Patients with chronic inflammatory skin conditions
• Patients with chronic lung diseases
• Patients with inflammatory respiratory diseases
• Patients with neoplasms such as: squamous cell carcinoma of the cervix, squamous cell carcinoma of the esophagus, lung adenocarcinoma, breast adenocarcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma
• History of active or passive smoking

Where it is running

• Azienda Ospedaliera di Padova — Padova, PD, Italy (enrolling)

Full record on ClinicalTrials.gov

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