Multimodal PET Imaging in the Diagnosis and Treatment of Pelvic Tumors

Recruiting now · Not applicable

Conditions studied: Endometrial Cancer

In brief

This study is a prospective exploratory study to explore the application value of gallium 68 labeled-fibroblast activation protein inhibitor-04 Positron Emission Tomography（68Ga-FAPI-04 PET）imaging in patients with endometrial cancer and compare it with the imaging agent with better imaging effects to study its advantages. After patient enrollment, 68Ga-FAPI-04 Positron Emission Tomography/Computed Tomography（PET/CT） and Positron Emission Tomography/Magnetic Resonance Imaging（PET/MRI） examinations are performed, with the imaging agent administered intravenously at a dose of 0.02 to 0.04 mCi/Kg×patient weight (Kg), and a whole-body scan is performed 30-60 minutes later, with images processed as usual. Within 1 week before and after the examination, Fluorine18 labeled-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography（18F-FDG PET/CT） is completed, along with medical history collection and necessary laboratory tests. Subsequently, patients undergo surgical resection of the lesion and suspicious metastatic lymph nodes shown by FAPI PET/CT to obtain the corresponding pathological results. Finally, the diagnostic value of all patients in 68Ga-FAPI-04 PET/CT and PET/MR is analyzed and compared with 18F-FDG PET/CT to study the differences in diagnostic efficacy between the two.

Key facts

Study ID

NCT06774209

Run by

Peking Union Medical College Hospital

People needed

30

Starts

2024-03-01

Expected to finish

2025-10-01

Last updated by the study team

2025-01-14

Who can join

Age: 18 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• 18-70 years old
• Obtaining written informed consent
• Being able to accept follow-up
• Feasible surgery or biopsy to obtain the final result

You may not qualify if…

• Pregnant and lactating female patients
• Patients who are difficult to receive further diagnosis and treatment due to their severe condition
• Any patients with contraindications to magnetic resonance imaging

Where it is running

• Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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