Application of Al18F-NOTA-Pentixafor PET/CT for Primary Aldosteronism

Recruiting now · Phase 1/Phase 2

Conditions studied: Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma

In brief

This prospective, single-center study investigates the biodistribution, dosimetry, safety, diagnostic performance of Al18F-NOTA-Pentixafor PET imaging in patients with primary aldosteronism. And evaluates the potential of Al18F-NOTA-Pentixafor PET imaging in surgical strategy guidance.

Key facts

Study ID

NCT06773663

Run by

Peking Union Medical College Hospital

People needed

150

Starts

2023-12-30

Expected to finish

2026-10-30

Last updated by the study team

2025-02-26

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with adrenal masses suspected to be aldosterone-producing adenomas based on routine imaging (e.g., CT scans), or clinically diagnosed primary aldosteronism patients requiring subtyping
• Signed written informed consent, with willingness and ability to comply with study procedures.
• Female participants must be surgically sterilized or postmenopausal for over a year; if not, reliable contraception is required.
• Male participants must use reliable contraception during the study and refrain from sperm donation.

You may not qualify if…

• Severe neurological disorders, or any significant diseases affecting the gastrointestinal, cardiovascular, hepatic, renal, hematological, oncological, endocrine, respiratory, or immune systems, or other serious illnesses.
• Diagnosis of claustrophobia.
• History of drug abuse or alcohol dependence.
• Pregnant or breastfeeding women.
• Poor venous access that would preclude repeated venipuncture.
• Use of experimental drugs or devices within one month prior to the study, where the safety or efficacy has not been established.
• Any condition that the study investigators deem could pose potential harm or jeopardize participant safety.

Where it is running

• Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College — Beijing, China (enrolling)

Full record on ClinicalTrials.gov

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