A Study of Enlicitide Decanoate (MK-0616), Warfarin, and Lisinopril in Healthy Adult Participants (MK-0616-026)

Completed · Phase 1

Conditions studied: Healthy

In brief

The main goal of this study is to learn what happens in a person's body over time when they take enlicitide decanoate with warfarin or lisinopril. Researchers want to learn if the amount of warfarin in a person's blood is similar when warfarin is taken alone or with enlicitide decanoate. Enlicitide decanoate is a new medicine that lowers the amount of cholesterol in a person's blood. Warfarin is a drug that reduces risk of blood clotting, and lisinopril is a drug that lowers blood pressure.

Key facts

Study ID

NCT06772779

Run by

Merck Sharp & Dohme LLC

People needed

36

Starts

2024-04-01

Expected to finish

2024-06-04

Last updated by the study team

2025-01-15

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The key inclusion criteria include but are not limited to:
• Is in good health
• Has a body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m\^2

You may not qualify if…

• The key exclusion criteria include but are not limited to:
• History of gastrointestinal disease which may affect food or drug absorption, or has had a gastric bypass or similar surgery
• History of cancer

Where it is running

• Celerion (Site 0001) — Tempe, Arizona, United States

Full record on ClinicalTrials.gov

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