Vancomycin Reduction Practices (VRP) in the NICU

Recruiting now · Not applicable

Conditions studied: Antibiotic Stewardship, Neonatal Sepsis, Late-Onset, Vancomycin

In brief

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.

Key facts

Study ID

NCT06772675

Run by

Children's Hospital of Philadelphia

People needed

13

Starts

2025-06-02

Expected to finish

2027-09-01

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Level III NICU
• Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN)
• Recruited by study team

You may not qualify if…

• Site not recruited for the study

Where it is running

• Kaiser Permanente Modesto Medical Center — Modesto, California, United States (enrolling)
• Kaiser Permanente East Bay - Oakland Medical Center — Oakland, California, United States (enrolling)
• Kaiser Permanente Roseville Medical Center — Roseville, California, United States (enrolling)
• Kaiser Permanente San Francisco Medical Center — San Francisco, California, United States (enrolling)
• Kaiser Permanente San Leandro Medical Center — San Leandro, California, United States (enrolling)
• Kaiser Permanente Santa Clara Medical Center — Santa Clara, California, United States (enrolling)
• Kaiser Permanente Walnut Creek Medical Center — Walnut Creek, California, United States (enrolling)
• Medical Center of Princeton — Plainsboro, New Jersey, United States (enrolling)
• Virtua Voorhees — Voorhees Township, New Jersey, United States (enrolling)
• Lancaster General Hospital — Lancaster, Pennsylvania, United States (enrolling)
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• Pennsylvania Hospital — Philadelphia, Pennsylvania, United States (enrolling)
• Chester County Hospital — West Chester, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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