Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Recruiting now
Conditions studied: Hemodynamic, Fluid Responsiveness, Venous Congestion, Fluid Challenge
In brief
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes. Venous congestion, a marker of impaired fluid clearance, is increasingly recognized as a significant contributor to poor prognosis. Previous studies have demonstrated the coexistence of fluid responsiveness and venous congestion in critically ill patients. Notably, these studies were limited by the absence of fluid challenge-the gold standard for assessing fluid responsiveness-leaving the dynamic relationship between fluid responsiveness and venous congestion incompletely understood. This study aims to investigate the interplay and temporal evolution of fluid responsiveness and venous congestion following a standardized fluid challenge in critically ill patients.
Key facts
- Study ID
- NCT06772038
- Run by
- Bicetre Hospital
- People needed
- 64
- Starts
- 2025-01-05
- Expected to finish
- 2025-07-30
- Last updated by the study team
- 2025-01-13
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Hospitalized in the intensive care unit (ICU)
- Hemodynamic monitoring in place, with a pulse wave contour analysis- derived estimation of cardiac output (either calibrated or uncalibrated)
- Decision made by clinicians to perform volume expansion through intravenous infusion of crystalloid fluid
You may not qualify if…
- Pregnancy
- Refusal to participate by relatives of the patient or the patient himself
Where it is running
- First affiliated Hospital , Sun Yat-sen University — Guangzhou, Guangdong, China (enrolling)
- Longgang Central Hospital of Shenzhen — Shenzhen, Guangdong, China (enrolling)
- Bicetre Hospital — Paris, Val-de-Marne, France (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.