Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease

Recruiting now · Not applicable

Conditions studied: Sickle Cell Disease

In brief

This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory strategy training to improve adherence to Cogmed in youth with sickle cell disease ages 7-16 years.

Key facts

Study ID

NCT06770010

Run by

Children's National Research Institute

People needed

50

Starts

2025-03-05

Expected to finish

2026-04-01

Last updated by the study team

2025-02-13

Who can join

Age: 7 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of sickle cell disease (any genotype).
• Between ages 7-16 years old.
• Patients will only enter the treatment phase if they score >1 SD below the normative mean on at least one standardized working memory assessment (i.e., Digit Span or Spatial Span subtests) or demonstrate a relative weakness in working memory (>1 SD below the estimated IQ).

You may not qualify if…

• Motor, visual, or auditory impairment that prevents computer use.
• Diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in the cognitive training.
• History of photosensitive seizures.
• Insufficient English fluency.
• Recent initiation or dose adjustment of a stimulant medication to treat attention problems (< 30 days).

Where it is running

• Children's National Hospital — Washington D.C., District of Columbia, United States (enrolling)

Full record on ClinicalTrials.gov

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