Electrophysiological Representations of Odor in the Human Brain Study 1

Recruiting now · Not applicable

Conditions studied: Odor Intensity Ratings

In brief

Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.

Key facts

Study ID

NCT06769464

Run by

Northwestern University

People needed

28

Starts

2024-04-01

Expected to finish

2028-08-01

Last updated by the study team

2025-01-13

Who can join

Age: 12 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 12 to 65, english speaker, patients undergoing brain surgery for treatment of medically intractable epilepsy

You may not qualify if…

• screening for history of smell or taste problems

Where it is running

• Northwestern University — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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