New Mechanisms of Obesity

Recruiting now · Not applicable

Conditions studied: Obesity and Overweight, Insulin Resistance, Obesity and Obesity-related Medical Conditions

In brief

Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.

Key facts

Study ID

NCT06768827

Run by

Yale University

People needed

55

Starts

2025-11-13

Expected to finish

2030-03-31

Last updated by the study team

2026-01-28

Who can join

Age: 15 and older, up to 22. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 15 to 22 years
• In puberty (girls and boys: Tanner stage III-V);
• BMI >85th

You may not qualify if…

• Pregnancy;
• endocrinopathies (e.g., Cushing syndrome);
• substance abuse;
• medications affecting insulin resistance such as metformin, GLP-1 analogues; -
• high fibers intake (> 30g/day) as assessed by a 3-day food record.

Where it is running

• Yale University — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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