The Impact of Melatonin Lotion on Sleep and Mental Health
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Sleep Problems, Depressive Disorder and Anxiety Disorders
In brief
The purpose of this study is to examine the effect that melatonin lotion has on sleep quality, the nervous system, and mental health. Melatonin is a hormone secreted by the brain that regulates sleep and might improve depression and anxiety symptoms. The goal is to determine whether melatonin in lotion form is an effective treatment for young adults with inadequate sleep and might improve mental health. Participants will fill out surveys, wear an actigraph (a wrist-worn device that measures sleep), wear a heart rate monitor (a strap worn around one's chest), and provide nightly saliva samples during treatment weeks. In one of the two treatment weeks, participants will receive a lotion that contains melatonin. During the other week they will receive a control treatment that will be lotion with no melatonin, and there will be a week in between with no treatment at all.
Key facts
- Study ID
- NCT06768749
- Run by
- University of Redlands
- People needed
- 60
- Starts
- 2025-02-28
- Expected to finish
- 2028-04-01
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- a T score ≥ 48 on the sleep disturbance short form Patient-Reported Outcomes Measurement Information System (PROMIS) measure, and
- a T score ≥ 55 on the anxiety or depression short form PROMIS measures (mild symptoms or more)
You may not qualify if…
- currently using antidepressant, anti-anxiety, or sleep medication including melatonin
- are pregnant
- have allergies/sensitivities to scented lotion
- are unwilling to commit to keeping a similar bedtime (± 1 hour) during treatment weeks.
Where it is running
- University of Redlands — Redlands, California, United States (enrolling)
Full record on ClinicalTrials.gov
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