Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy
Recruiting now · Not applicable
Conditions studied: Pain Management, Pain, Postoperative
In brief
This is a prospective randomized open-label noninferiority trial that compares intrathecal morphine injection and continuous wound infiltration after open pancreaticoduodenectomy.
Key facts
- Study ID
- NCT06761989
- Run by
- Seoul National University Hospital
- People needed
- 104
- Starts
- 2025-01-15
- Expected to finish
- 2027-01-07
- Last updated by the study team
- 2025-03-19
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults 19 years of age or older
- Scheduled for elective open pancreaticoduodenectomy or pylorus preseriving pancreaticoduodenectomy
- Disease of periampullary lesions
- Perfromance status assessed with ECOG score is 0 or 1 at the time of enrollment
- Able to provide written informed consent to participate in the study, understand the procedures of this study, and complete patient-reported questionnaires
- American Society of Anesthesiologists physical status I to III
You may not qualify if…
- Hypersensitivity to medications used for pain control (fentanyl, ropivacaine, morphine, acetaminophen, NSAIDs)
- Cognitive impairment that affects using patient-controlled analgesia device or answering patient-reported questionnaires
- Infection or anatomical abnormalities of the abdominal wall and skin that preclude catheterization for continuous wound infiltration
- Contraindicated for intrathecal injection due to any coagulation disorder or continued use of anticoagulants
- Have a major medical or psychiatric illness that would affect response to treatment
- History of chronic pain, or chronic use of analgesics or psychiatric medications
- Have severe liver or kidney disease
- Anyone who are not appropriate for the study in the opinion of the investigators
Where it is running
- Seoul National University Hospital — Seoul, Seoul, South Korea (enrolling)
Full record on ClinicalTrials.gov
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