Is Negativity of Autoantibodies a Marker of Severity in Auto-immune Hepatitis?
Recruiting now
Conditions studied: Auto-immune Hepatitis
In brief
Evaluate the proportion of seronegative auto-immune hepatitis and a possible relationship with the severity of the disease. Criteria of severity will be defined by corticodependance, corticoresistance and a severe form of the disease at diagnosis (cirrhosis or fulminant hepatitis). In case of predominant seronegative forms, other auto-antibodies related to this auto-immue hepatitis will be searched.
Key facts
- Study ID
- NCT06761209
- Run by
- Centre Hospitalier Universitaire de la Guadeloupe
- People needed
- 100
- Starts
- 2022-07-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-01-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- - Any patient over 18 years old
- Patient followed at Hôpital Saint-Antoine or treated for HAI or in Guadeloupe within the framework of the CCRD Filfoie for an acute or chronic AIH under immunosuppressive treatment
- Patient affiliate or beneficiary of a social security scheme
- Free, informed and written consent signed by the patient and the investigator
- o exclusion criteria: - Patient under 18 years old
- Patient not able to give his/her consent
- Viral hepatitis: viruses A to E, Epstein-Barr virus, cytomegalovirus and herpes simplex virus
- Isolated primary biliary cholangitis
- Isolated primary sclerosing cholangitis
- Drug-induced liver injury
- Wilson disease
- Alcoholic hepatitis
- Hemochromatosis
- Sickle cell disease and heart liver
- Non-alcoholic steato-hepatitis
Where it is running
- CHU de Pointe-à Pitre — Pointe à Pitre, Guadeloupe, France (enrolling)
- Hospital of Saint-Antoine — Paris, France, France
Full record on ClinicalTrials.gov
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