Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Recruiting now
Conditions studied: Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity, Neurodegenerative Diseases
In brief
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent. Also, SDB shows high comorbidities with multisystem diseases. Furthermore, compared to patients with pure SDB, those comorbid with SDB and other disorders like cardiometabolic dysfunction and cognitive impairment experience poorer quality of life, higher rate of disease progression and mortality, and a greater economic burden. Currently, there are limited cohorts to study the associations between SDB and multisystem diseases. The aim of this study is to establish an ambispective clinical cohort for SDB in Xiangya hospital from central-south China (Xiangya Sleep Disordered Breathing Cohort, Xiangya SDB cohort) including retrospective part and prospective part, which covers multi-dimensional data of sleep monitoring, demographic, daily behaviors, clinical manifestations and comorbidities status, life quality, treatment information and evaluation, etc. by self-reported questionnaires and objective assessments and tests. Besides, whole peripheral blood is drawn for following biomarkers study and omics analysis. The main goal is to achieve precise management of SDB and related multimorbidity, containing to early identify risk individuals for multisystem impairment, significantly improve their prognosis and ultimately enhance overall health. In detail: first, to reveal how multisystem impairment related to SDB evolves; second, to identify which indicators closely involve system dysfunction due to SDB; third, to build an efficient model and a cost-effective platform to screen high-risk population and tract therapeutic effect.
Key facts
- Study ID
- NCT06755840
- Run by
- Xiangya Hospital of Central South University
- People needed
- 15000
- Starts
- 2025-01-15
- Expected to finish
- 2035-10-31
- Last updated by the study team
- 2025-04-03
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 1) Participants who were suspected of sleep disordered breathing must complete at least one overnight sleep monitoring at the Sleep Medicine Center at Xiangya Hospital.
- 2) Participants can finish any assessment for each comorbid system by questionnaires, scales, physical examinations and tests, etc. independently or with the assistance.
- 3) Participants agreed to participate in this study with signing an informed consent form.
You may not qualify if…
- Participants who refused to participate in this study or whose clinical data was lost.
Where it is running
- Xiangya Hospital of Central South University — Changsha, China (enrolling)
Full record on ClinicalTrials.gov
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