The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Recruiting now
Conditions studied: Periodontitis, End-stage Renal Disease
In brief
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
Key facts
- Study ID
- NCT06755372
- Run by
- Ain Shams University
- People needed
- 100
- Starts
- 2025-04-01
- Expected to finish
- 2025-08-01
- Last updated by the study team
- 2025-07-04
Who can join
Age: 30 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with Periodontitis stage II and/or stage III
- Systemically healthy, no history of systemic diseases
- Not on long-term medications
You may not qualify if…
- Smokers
- Individuals with any systemic disease or long-term medication use
- Group II: ESRD Patients with Periodontitis
- Inclusion Criteria:
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with end-stage renal disease (ESRD) on regular hemodialysis
- Diagnosed with Periodontitis stage II and/or stage III
- Unrelated Egyptians from a similar socioeconomic status, residing in the same geographical area
- Underlying type 2 diabetes mellitus
- Exclusion Criteria:
- Individuals with kidney transplants
- Individuals with systemic diseases other than diabetes
- History of malignancy
- Smokers
Where it is running
- hemodialysis center at Benha University Hospital. — Al Fayyum, Faiyum Governorate, Egypt (enrolling)
Full record on ClinicalTrials.gov
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