The Effects of Cannabis on Male Reproductive Functions
Starting soon · Phase 1 · Has a placebo group
Conditions studied: Male Reproductive Problem
In brief
The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute effects of cannabis use on male reproductive functions. Specifically, the investigators will examine the dose-dependent effects of acute cannabis use on male reproductive parameters, including sperm counts, motility, morphology, and testosterone levels, as well as sperm epimutations. Participants \[cannabis users will be randomly assigned to 1) non-vaping, 2) placebo (vaping without cannabis), and 2 doses of cannabis, 3) 20 and 4) 40mg of THC in cannabis flower obtained from the NIDA drug supply\], and 5) non-cannabis users (naïve control, no cannabis or placebo exposure). Participants will provide surveys (cannabis use and sexual functioning and satisfaction etc.), peripheral blood, and semen.
Key facts
- Study ID
- NCT06755346
- Run by
- Kanako Hayashi
- People needed
- 100
- Starts
- 2025-04-01
- Expected to finish
- 2027-03-30
- Last updated by the study team
- 2025-01-03
Who can join
Age: 21 and older, up to 64. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Regular cannabis users (21\~64 years-old men) who have used cannabis at least once a week for at least once a year or who have never used cannabis.
- Willingness to abstain from using cannabis on the day of the testing session (minimum 5 hours abstinence).
You may not qualify if…
- Women
- Adult men, 65 or older, and men under the age of 21
- Serious psychiatric conditions (e.g. psychosis, bipolar I and panic disorder)
- Family history of psychosis
- Chronic medical conditions (e.g., heart disease, diabetes)
- History of adverse experiences with cannabis (e.g., anxiety and panic attacks)
- Use of other illicit drugs (not cannabis) in the past 2 months
- Heavy alcohol use (>4 drinks, >4 times/week)
- Smoking/nicotine use
- Infrequent cannabis use (less than once a week for only cannabis users)
- BMI over 34
- Current use of corticosteroids and blood thinners
Where it is running
- Washington State University — Pullman, Washington, United States
Full record on ClinicalTrials.gov
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