The Effect of Injectable Platelet-Rich Fibrin in Peri-implant Soft Tissue

Recruiting now · Not applicable

Conditions studied: Peri-Implant Tissues

In brief

An inadequate amount of peri-implant soft tissue results in more plaque accumulation around the implants, peri-implant mucositis, marginal bone loss, mucosal recession, and/or attachment loss. In the literature, there are studies evaluating the application of injectable platelet-rich fibrin to the gingiva and oral mucosa around teeth, but injectable platelet-rich fibrin application around implants has not been encountered. This study aimed to evaluate the effect of subgingival and submucosal application of injectable platelet-rich fibrin on peri-implant soft tissue phenotype in patients with inadequate peri-implant soft tissue phenotype.The study will include 80 systemically healthy and non-smoking patients/implants older than 18 years of age with insufficient peri-implant keratinized mucosa width and mucosal thickness who applied to Kütahya University of Health Sciences, Faculty of Dentistry, Department of Periodontology. There are two study groups according to peri-implant mucosa phenotype: Thin phenotype and thick phenotype. All patients will undergo the same procedure of injectable platelet-rich fibrin application

Key facts

Study ID

NCT06753396

Run by

Kutahya Health Sciences University

People needed

80

Starts

2022-12-15

Expected to finish

2026-04-15

Last updated by the study team

2025-09-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• be over 18 years old
• The patient does not have any systemic disease
• Patients who do not smoke or who smoke less than 10 cigarettes
• Peri-implant keratinized mucosa width less than 2 mm
• Peri-implant mucosal thickness less than 2 mm

You may not qualify if…

• Being out of the defined age group
• Any systematic contraindication for periodontal surgery
• Patients who smoke more than 10 cigarettes per day
• Patients with adequate peri-implant keratinized mucosa width and mucosal thickness
• Pregnancy
• Patients taking medication that suppresses the immune system or impairs healing
• Patients taking medication that impairs the bleeding condition

Where it is running

• Kütahya Health Sciences University Faculty of Dentistry — Kütahya, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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