The Effect of Ozone Therapy on Gingivoplasty

Recruiting now · Not applicable

Conditions studied: Gingival Enlargement

In brief

Ozone therapy after gingivectomy and gingivoplasty has been found to reduce patients' pain levels and positively impact their quality of life. This study aimed to compare the healing potential of the wound surface following gingivectomy and gingivoplasty surgery applied to the maxillary anterior regions with classical periodontal paste application (Coe-pak) using activated oxygen (Cure 09 Active Oxygen) and classical periodontal paste application only (Coe-pak). The study will include 48 systemically healthy patients older than 18 years of age with gingival enlargement in the maxillary anterior region, requiring gingivectomy and gingivoplasty surgery, who applied to Kütahya University of Health Sciences, Faculty of Dentistry, Department of Periodontology and Izmir Democracy University, Faculty of Dentistry, Department of Periodontology. Patients will be evaluated in two different groups as test and control group after surgery. Patients will be randomly divided into study groups by closed envelope method. The test group will receive periodontal paste (Coe-pak) + Ozone therapy (active oxygen (Cure 09 Active Oxygen)) after gingivectomy and gingivoplasty surgery, while the control group will receive only periodontal paste after gingivectomy and gingivoplasty surgery. All patients will undergo gingivectomy and gingivoplasty with the same procedure

Key facts

Study ID

NCT06753305

Run by

Kutahya Health Sciences University

People needed

48

Starts

2022-11-15

Expected to finish

2026-04-15

Last updated by the study team

2025-09-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• be over 18 years old
• Systemically healthy individuals
• Gingival enlargement due to inflammation in at least 4 teeth in the maxillary anterior region
• Horizontal and vertical gingival growth index score of 1 or 2
• Gingival thickness more than 2 mm
• Good oral hygiene
• No loss of clinical attachment

You may not qualify if…

• Pregnancy
• Hereditary gingival fibromatosis
• Drug-induced gingival enlargement
• Allergy
• Presence of systemic conditions requiring antibiotic prophylaxis
• Acute and untreated periodontitis

Where it is running

• Kütahya Health Sciences University Faculty of Dentistry — Kütahya, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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