Clinical Management and Outcomes of Primary Ovarian Leiomyosarcoma

Recruiting now

Conditions studied: Primary Ovarian Leiomyosarcoma

In brief

This observational study aims to gather comprehensive data on primary ovarian leiomyosarcoma (POLMS). This extremely rare malignancy accounts for less than 3% of primary ovarian malignancies and has an incidence of only 1% among ovarian cancers. This national, retrospective and prospective multicenter study will collect and analyze historical cases of POLMS with remote diagnoses accessed through clinical case reviews and newly identified cases. The study aims to expand a previously identified series of 113 cases described in the literature, uncovering patterns in diagnosis, treatment, and outcomes and ultimately establishing evidence-based guidelines for the optimal management of this rare and aggressive cancer.

Key facts

Study ID

NCT06749600

Run by

Azienda USL Reggio Emilia - IRCCS

People needed

30

Starts

2024-06-14

Expected to finish

2027-12-31

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 99. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of primary leiomyosarcoma of the ovary;
• Patients diagnosed with POLMS for whom data relating to diagnosis and treatment are available.
• Aged between 18 and 99 years

You may not qualify if…

• All patients with other forms of ovarian sarcoma (rhabdomyosarcomas, fibrosarcomas, stromal cell sarcomas) and patients diagnosed with leiomyosarcoma of the uterus will be excluded.

Where it is running

• AOU Policlinico di Modena — Modena, Italy, Italy (enrolling)
• Azienda Ospedaliero Universitaria di Parma - S.C. Ostetricia e Ginecologia — Parma, PR, Italy (enrolling)
• Azienda USL IRCCS di Reggio Emilia — Reggio Emilia, RE, Italy (enrolling)
• Malzoni - Avellino — Avellino, Italy (enrolling)
• Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco" - Catania — Catania, Italy (enrolling)
• IRCCS Ospedale San Raffaele — Milan, Italy (enrolling)
• Fondazione Irccs San Gerardo Dei Tintori — Monza, Italy (enrolling)
• IRCCS Istituto Nazionale Tumori Fondazione Pascale — Naples, Italy (enrolling)
• Università degli Studi di Napoli Federico II — Naples, Italy (enrolling)
• Ospedale "Sacro Cuore" — Verona, Italy (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.