A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Staphylococcus Aureus

In brief

The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis through a central venous catheter (Phase IIa).

Key facts

Study ID

NCT06749457

Run by

AstraZeneca

People needed

231

Starts

2024-12-30

Expected to finish

2028-01-07

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Phase I:
• Participant must be 18 to 55 years of age (inclusive), at the time of signing the informed consent.
• Body weight ≥ 45 kilograms (kg) and ≤ 110 kg and Body Mass Index (BMI) within the range ≥ 18.0 to ≤ 30.0 kilograms per square meter (kg/m2) (inclusive) at screening.
• Healthy participants with no clinically significant concomitant diseases or medications (except for those specifically permitted by the protocol) according to medical history, physical examination, screening safety laboratory tests, and screening parameters, as perthe judgement of the investigator.
• Phase IIa:
• Participant must be ≥ 18 years of age at the time of signing the informed consent.
• Participants who meet all of the following disease status requirements:
• Diagnosed with End-stage kidney disease (ESKD).
• Requiring hemodialysis through a tunneled central venous catheter as the primary vascular access for hemodialysis.
• Receiving hemodialysis for treatment of ESKD for at least 90 days before randomization.
• At least 3 previous dialysis sessions using current dialyzer.
• Receiving adequate hemodialysis based on a single-pool Kt/V measurement > 1.2 within the last 30 days.
• No new medications have been added to the participant's regimen in the last 2 weeks prior to dosing. 'New medication' is defined as any medication that has not been prescribed or used by the participant previously (including formulation changes). Medication previously prescribed or used by the participant with dose adjustments is allowed and not considered as new medication for the purpose of this study.
• Not taking long-term systemic antibiotics with activity against S aureus.

You may not qualify if…

• Phase I:
• Known hypersensitivity to any component of the study intervention
• Previous hypersensitivity, infusion-related reaction, or severe adverse reaction following administration of monoclonal antibodies (mAbs).
• Clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following intramuscular injections or venipuncture.
• Aspartate Aminotransferase (AST) or alanine Aminotransferase (ALT) above 1.5 × upper limit of normal (ULN) at screening. Testing may be repeated once at the investigator's discretion.
• Estimated glomerular filtration rate < 90 mL/min/1.73 m2 calculated using the Chronic Kidney Disease Epidemiology Collaboration equation at screening.
• Hemoglobin or platelet count below the lower limit of normal at screening. Testing may be repeated once at the investigator's discretion.
• White blood cell counts outside normal reference ranges unless judged by the investigator to be out of range given the known variation in white blood cell count reference interval by ethnicity. Testing may be repeated once at the investigator's discretion.
• History of malignancy other than treated non-melanoma skin cancers or locally treated cervical cancer in the previous 5 years.
• Any laboratory value in the screening panel that, in the opinion of the investigator, is clinically significant or might confound analysis of study results. Testing may be repeated once at the investigator's discretion.
• Any clinically significant abnormalities on 12-lead electrocardiogram (ECG) at screening, as judged by the investigator.
• Acute (time-limited) illness, including fever ≥ 38 °C (100.4 °F), one day prior to or on day of planned dosing; participants excluded for transient acute illness may be dosed if illness resolves within the 28-day Screening Period or may be rescreened once.
• Known or suspected congenital or acquired immunodeficiency, or receipt of immunosuppressive therapy, including any course of glucocorticoid therapy exceeding 2 weeks of prednisone or equivalent at a dose of 20 mg daily or every other day within 6 months prior to screening.
• Any condition that has the potential to increase clearance of the study intervention (eg, protein loss conditions such as severe enteropathies, or plasmapheresis).
• Blood drawn in excess of a total of 450 milliliters (mL) (1 unit) for any reason within 2 months prior to screening.
• Absence of suitable veins for blood sampling and administration of study intervention.
• Any other condition that would compromise safety of the participants.
• Any condition that, in the opinion of the investigator, might interfere with evaluation of the study intervention or interpretation of participant safety or study results.
• Phase IIa:
• Known hypersensitivity to any component of the study intervention.
• History of allergic disease or reactions likely to be exacerbated by any component of the study intervention as listed in dose formulation section.
• Previous hypersensitivity, infusion-related reaction, or severe adverse reaction following administration of mAbs.
• Hemoglobin < 9 g/dL at screening considered by the investigator to be due to acute condition(s). Testing may be repeated once at the investigator's discretion.
• Serum albumin of < 3 g/dL at screening considered by the investigator to be due to acute condition(s). Testing may be repeated once at the investigator's discretion.
• Myocardial infarction, acute coronary syndrome, stroke, seizure, or a thrombotic/thromboembolic event (eg, deep vein thrombosis or pulmonary embolism, but excluding vascular access thrombosis) within 90 days prior to randomization.

Where it is running

• Research Site — San Dimas, California, United States (enrolling)
• Research Site — Beaumont, Texas, United States (enrolling)
• Research Site — Dallas, Texas, United States (enrolling)
• Research Site — Houston, Texas, United States (enrolling)
• Research Site — McAllen, Texas, United States (enrolling)
• Research Site — Chula Vista, California, United States (enrolling)
• Research Site — Glendale, California, United States (enrolling)
• Research Site — Granada Hills, California, United States (enrolling)
• Research Site — Los Angeles, California, United States (enrolling)
• Research Site — Northridge, California, United States (enrolling)
• Research Site — Northridge, California, United States (enrolling)
• Research Site — Oxnard, California, United States (enrolling)
• Research Site — Riverside, California, United States (enrolling)
• Research Site — Huntsville, Alabama, United States (enrolling)
• Research Site — Tarzana, California, United States (enrolling)
• Research Site — Valencia, California, United States (enrolling)
• Research Site — Victorville, California, United States (enrolling)
• Research Site — Englewood, Colorado, United States (enrolling)
• Research Site — Bradenton, Florida, United States (enrolling)
• Research Site — Coral Springs, Florida, United States (enrolling)
• Research Site — Hollywood, Florida, United States (enrolling)
• Research Site — Orlando, Florida, United States (enrolling)
• Research Site — Tampa, Florida, United States (enrolling)
• Research Site — Lawrenceville, Georgia, United States (enrolling)
• Research Site — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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