Dissecting the Roles of High-quality Diets and Ultra Processed Foods on Cardiometabolic Health

Starting soon · Not applicable

Conditions studied: Cardiometabolic Risk Factors

In brief

Controversy remains around the role of ultra-processed food (UPF) consumption and health outcomes. A key question that remains to be answered is: when diet quality is the same, does food processing itself have any independent health effects? The current application aims to isolate the health effects of food processing from those of diet quality through the conduct of a dietary intervention study.

Key facts

Study ID

NCT06749327

Run by

Queen's University, Belfast

People needed

330

Starts

2026-10-01

Expected to finish

2029-06-01

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women aged between 18 and 65 years in general good health with BMI < 35 kg/m2 who can provide informed consent.

You may not qualify if…

• Participants will be ineligible to enrol if they have diabetes, CVD, any type of cancer (except for basal cell skin cancer), or a condition (pregnancy, breastfeeding, etc) or dietary restriction(s) that would substantially limit their ability to complete the study.
• Individuals will be screened for their adherence to the Plant based diet Index (PDI ).
• Individuals with low adherence will enter run-in phase only (6 weeks)
• Individuals with high adherence will enter the main intervention (4 months)

Where it is running

• University College Dublin — Dublin, Ireland, Ireland
• Centre for Public Health, Queen's University Belfast — Belfast, Northern Ireland, United Kingdom

Full record on ClinicalTrials.gov

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