Plaque Imaging in Routine Care to Detect Intraplaque Hemorrhage

Recruiting now

Conditions studied: Acute Ischemic Stroke

In brief

The aim of this study is to investigate the association between intraplaque hemorrhage (IPH) detected by non-contrast magnetic resonance imaging (MRI) of the carotid artery in routine clinical practice and ipsilateral acute ischemic events. The investigators' overarching aim is to determine whether this sequence aids the diagnostic work-up of stroke patients. For this purpose, the investigators set up a prospective single-center longitudinal observational study with one year follow-up. In addition, this study will analyze retrospectively obtained data collected through clinical routine.

Key facts

Study ID

NCT06749106

Run by

Ludwig-Maximilians - University of Munich

People needed

300

Starts

2025-01-16

Expected to finish

2029-12-31

Last updated by the study team

2025-01-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with acute ischemic stroke
• Availability of non-contrast carotid MRI scans obtained through routine diagnostic work-up

You may not qualify if…

• Infarct in the posterior circulation or bilateral ischemic infarcts
• Time between symptom onset and non-contrast carotid MRI > 10 days
• Prior stenting of a carotid artery or carotid endarterectomy
• Age < 18 years
• Life expectancy < 1 year
• Inability to provide written informed consent
• This eligibility criteria apply for the prospective part of the PARADE study.

Where it is running

• Institute for Stroke and Dementia Research — Munich, Germany (enrolling)

Full record on ClinicalTrials.gov

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