IO Vancomycin Spine

Starting soon · Phase 2/Phase 3

Conditions studied: Lumbar Fusion Surgery

In brief

The goal of this research is to learn if injecting the antibiotic vancomycin directly into the bone marrow (intraosseous) or IO) during a lumbar (spinal) fusion surgery, is as effective or better than the standard method of giving it vancomycin through a vein (intravenous) or IV) during lumbar fusion surgery.

Key facts

Study ID

NCT06748144

Run by

The Methodist Hospital Research Institute

People needed

30

Starts

2026-05-01

Expected to finish

2030-04-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is undergoing open posterior instrumented spinal fusion (PSIF) or transforaminal lumbar interbody fusion (TLIF)
• Patient is able to give informed consent to participate on the study. LAR consents will not be utilized for this study
• Age Range >18

You may not qualify if…

• Previous spine surgery if surgeon deems it will affect the study
• BMI > 40
• Contraindication to receiving vancomycin, cefepime, ancef, or other standard of care pre-operative antibiotic (allergy, medical issue, etc).
• Inability to administer the IO infusion
• Refusal to participate
• Diabetes as defined as uncontrolled A1C > 7.5 and eGFR <59
• Immunocompromised or immunosuppressed patients (HIV, Hep C, ESRD, dialysis, transplant, chemo/radiation treatment in last 6 months, medications)
• No vulnerable populations

Where it is running

• Houston Methodist Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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