IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression

Running, not enrolling · Not applicable

Conditions studied: Depression During Pregnancy, Depression, Postpartum

In brief

The goal of this clinical trial is to evaluate if a digital group intervention (named IMAGINE) can prevent depression in perinatal populations. The main questions it aims to answer are: Does IMAGINE engage cognitive behavioral therapy targets? Does IMAGINE lead to lower depression scores? Is IMAGINE acceptable, appropriate, usable and feasible? Participants will be randomized to either participate in an IMAGINE group for 12 weeks or receive standard of care. Participants will respond to questionnaires at enrollment and study visits at 12 and 24 weeks after enrollment.

Key facts

Study ID

NCT06746337

Run by

University of Washington

People needed

100

Starts

2025-03-10

Expected to finish

2026-10-31

Last updated by the study team

2026-05-26

Who can join

Age: 16 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Pregnant or up to 6 months postpartum
• Age 16 or over
• At elevated risk of perinatal depression (per USPSTF)
• Speaks English or Spanish
• PHQ9<15 and no current major depression
• Access to a smartphone with cellular data at least 3 days per week
• If receiving other mental healthcare services, has been established in care at least 6 months and on stable treatment regimen
• Exclusion Criteria: none

Where it is running

• Perinatal Support Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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