Carotid Sinus Massage in Trendelenburg Position for Headache Relief

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Migraine, Tension-Type Headache

In brief

Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types. There is growing evidence suggesting that blood pressure regulation and baroreceptor activity play a role in headache pathophysiology. Carotid sinus massage (CSM), particularly when combined with the modified Trendelenburg position, may modulate autonomic nervous system activity to relieve headache symptoms. An initial open-label pilot study (n = 17) was completed, and the results were published in a preprint server for health sciences, the Medical Research Archive (medRxiv), demonstrating the feasibility, safety, and promising preliminary efficacy of CSM+T. Based on these findings, a follow-up randomized, sham-controlled, parallel-arm trial will further evaluate the efficacy of the treatment.

Key facts

Study ID

NCT06745648

Run by

Hospital Municipal Pedro T. Orellana

People needed

18

Starts

2024-12-21

Expected to finish

2025-12-30

Last updated by the study team

2025-06-15

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must be at least 16 years of age.
• Must have a diagnosis of one of the following, according to the International Classification of Headache Disorders (ICHD-3):
• Migraine
• Tension-type headache
• Mixed headache
• The headache episode must have started within the past 24 hours.

You may not qualify if…

• Any contraindication to carotid sinus massage, including:
• Carotid bruits
• Recent myocardial infarction
• History of stroke
• Known or suspected carotid artery stenosis
• Any contraindication to the Trendelenburg position, including:
• Increased intracranial pressure
• Respiratory distress
• Congestive heart failure
• History of syncope
• History of cardiac arrhythmias

Where it is running

• Hospital Pedro T.Orellana, Trenque Lauquen — Trenque Lauquen, Buenos Aires, Argentina (enrolling)

Full record on ClinicalTrials.gov

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