Exploring the Benefit of Topical Capsaicin in Treating Pain From Chemo-induced Peripheral Neuropathy: a Longitudinal Single Center Pilot Study

Recruiting now · Early Phase 1

Conditions studied: Peripheral Neuropathy Due to Chemotherapy

In brief

To learn if topical capsaicin can help relieve pain from CIPN and improve gait (the pattern of walking) in patients.

Key facts

Study ID

NCT06744816

Run by

M.D. Anderson Cancer Center

People needed

20

Starts

2025-12-11

Expected to finish

2027-11-30

Last updated by the study team

2026-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants diagnosed with pain of the lower extremity from chronic (>90 days duration) CIPN (due to either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds), seen at MD Anderson Cancer Center
• Participants reporting baseline pain ≥ 4 (0-10 scale, NRS)
• Participants age 18+
• Participants who have completed chemotherapy within the last year at the time of enrollment.

You may not qualify if…

• Participants with cognitive dysfunction
• Participants with recent history (<6 months) of drug or alcohol abuse
• Participants with open skin lesion or undergoing antibiotic therapy for local for systemic infection
• Participants with allergies to capsaicin or adhesives
• Pregnant participants

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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