Pulsed Electromagnetic Fields in Preventing Physical Deconditioning in Patients Undergoing Prolonged Hospitalization

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Haematological Cancer, Healthy

In brief

The goal of this clinical trial is to examine if pulsed electromagnetic fields (PEMF) can prevent or decrease physical deconditioning associated with prolonged hospitalisation and immobility of haematology patients. The main question\[s\] it aims to answer \[is/are\]: * Does haematology patients undergoing prolonged hospitalisation have no or decreased physical deconditioning when exposed to PEMF? * What are the changes in muscle secretome at baseline and after exposure to PEMF? Researchers will compare haematology patients who receive PEMF against patients who did not receive the treatment to see if there is a change in physical deconditioning. Healthy volunteers will also be recruited and randomized to either exposure to PEMF or no exposure. Haematology patients will * Have their blood taken at baseline, 4 weeks from baseline and 8 weeks from baseline. * Undergo SPPB test at baseline, 4 weeks and 8 weeks from baseline, and the test comprises of the time up and go test, 4 minute walk test and sit to stand test. * Either expose to PEMF twice per week for 4 consecutive weeks or no exposure. Healthy volunteers will * Have their blood taken at baseline, 4 weeks from baseline and 8 weeks from baseline. * Either expose to PEMF twice per week for 4 consecutive weeks or no exposure.

Key facts

Study ID: NCT06744764
Run by: National University Hospital, Singapore
People needed: 76
Starts: 2023-04-17
Expected to finish: 2025-12-01
Last updated by the study team: 2025-01-08

Who can join

Age: 25 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Haematology patients who are undergoing induction chemotherapy for acute leukemia
Haematology patients who are undergoing haematopoietic stem cell transplant
Have ECOG 0-24. Able to walk at baseline to participate in short physical battery test.
For healthy volunteers, subjects have to be healthy without any major disease states, not on any drugs or requiring long term medical attention.

You may not qualify if…

Patients who do not agree to sign the consent form.
Pregnant women will be excluded from the study for healthy volunteers

Where it is running

National University Hospital — Kent Ridge, Singapore (enrolling)
NUHS Investigational Medicine Unit — Kent Ridge, Singapore

Full record on ClinicalTrials.gov

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