Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck
Recruiting now
Conditions studied: Squamous Cell Carcinoma of Head and Neck
In brief
This study will test the ability of a personalized blood test to determine which head and neck cancer patients will have a recurrence after treatment.
Key facts
- Study ID
- NCT06744296
- Run by
- Massachusetts Eye and Ear Infirmary
- People needed
- 75
- Starts
- 2025-02-03
- Expected to finish
- 2029-01-06
- Last updated by the study team
- 2025-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Newly diagnosed AJCC 8th edition Stage III-IVB mucosal SCC of the head and neck, which includes tumors arising from the oral cavity, nasal cavity, paranasal sinuses, nasopharynx, oropharynx, hypopharynx, and larynx.
- Available tissue for tumor-informed ctDNA panel creation.
- Definitive treatment with standard of care surgery or chemoradiotherapy is planned to be administered at Massachusetts Eye and Ear Institute (MEEI) or within the Massachusetts General Hospital (MGH) Cancer Center (including but not limited to the Boston, Danvers, and Newton-Wellesley locations).
You may not qualify if…
- Patients <18 years of age
- Patients receiving non-standard of care therapy as determined by the clinical investigator
- Participants who have undergone prior surgical resection, excisional biopsy, radiation, and/or chemotherapy for the treatment of HNSCC. Prior incisional biopsies are permitted. Discrepant cases will be reviewed by study PI.
- Participants who are receiving any investigational agents at the time of enrollment.
- Participants with AJCC Stage IVC HNSCC, which includes patients with biopsy-confirmed distant metastatic HNSCC, including but not limited to metastatic spread to the lungs, bones, or liver.
- Active non-HNSCC malignancy.
- Active pregnancy during treatment.
Where it is running
- Massachusetts Eye and Ear — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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