A Study on the Safety and Immunogenicity of Hexavalent Influenza mRNA Vaccine in Adult Participants 50 Years of Age and Older

Completed · Phase 1/Phase 2

Conditions studied: Influenza, Healthy Volunteers

In brief

The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular injection of different formulations of a hexavalent influenza messenger ribonucleic acid (mRNA) vaccine composed of differing dose levels of trivalent (TIV) mRNA hemagglutinin (HA) in combination with TIV mRNA-neuraminidase (NA) compared to an active control ((Fluzone standard-dose quadrivalent influenza vaccine (QIV-SD) or Fluzone high-dose quadrivalent influenza vaccine (QIV-HD) in adults 50 years of age and older.

Key facts

Study ID

NCT06744205

Run by

Sanofi Pasteur, a Sanofi Company

People needed

1162

Starts

2025-01-06

Expected to finish

2026-05-22

Last updated by the study team

2026-06-09

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participant aged 50 years on the day of inclusion
• A female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies:
• Is of non-childbearing potential. To be considered of non-childbearing potential, a female must be postmenopausal for at least 1 year, or surgically sterile.
• OR
• Is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to study intervention administration until at least 12 weeks after study intervention administration.
• A female participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours prior to administration of study intervention.

You may not qualify if…

• Participants are not eligible for the study if any of the following criteria are met:
• Known or suspected congenital or acquired immunodeficiency; or receipt of immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy, within the preceding 6 months; or long-term systemic corticosteroid therapy (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months)
• Known systemic hypersensitivity to any of the study intervention components (eg, polyethylene glycol, polysorbate); history of a life-threatening reaction to the study interventions used in the study or to a product containing any of the same substances; any allergic reaction (eg, anaphylaxis) after administration of mRNA vaccine
• Previous history of myocarditis, pericarditis, and/or myopericarditis
• Known history of previous episodes of Guillain-Barré syndrome, neuritis (including Bell's palsy), convulsions, encephalitis, transverse myelitis, and vasculitis
• Participants with an electrocardiogram that is consistent with possible myocarditis or pericarditis or, in the opinion of the investigator, demonstrates clinically relevant abnormalities that may affect participant safety or study results
• Self-reported thrombocytopenia, contraindicating intramuscular (IM) vaccination based on Investigator's judgment
• Bleeding disorder, or receipt of anticoagulants in the 3 weeks preceding inclusion, contraindicating IM vaccination based on Investigator's judgment
• Chronic illness that, in the opinion of the Investigator, is at a stage where it might interfere with study conduct or completion
• Moderate or severe acute illness / infection (according to investigator's judgement) or febrile illness (temperature ≥ 38.0°C [≥ 100.4°F]) on the day of vaccination. A prospective participant should not be included in the study until the condition has resolved or the febrile event has subsided.
• Alcohol, prescription drug, or substance abuse that, in the opinion of the Investigator, might interfere with the study conduct or completion
• Participant who had acute infectious symptoms or a positive SARS-CoV-2 RT-PCR or antigen test in the past 10 days prior to the first visit (V01)
• Receipt of any vaccine in the 4 weeks preceding study intervention administration or planned receipt of any vaccine in the 4 weeks following study intervention administration
• Receipt of immune globulins, blood or blood-derived products in the past 3 months
• Previous vaccination against influenza in the previous 6 months with an investigational or marketed vaccine
• Receipt of any mRNA vaccine/product in the 2 months preceding study intervention administration or planned receipt of any mRNA vaccine in the 2 months after study vaccination
• Participation at the time of study enrollment (or in the 4 weeks preceding study intervention administration) or planned participation during the present study period in another clinical study investigating a vaccine, drug, medical device, or medical procedure
• Self-reported or documented seropositivity for human immunodeficiency virus, hepatitis B virus, or hepatitis C virus

Where it is running

• Accel Research Sites Network - Birmingham- Site Number : 8400008 — Birmingham, Alabama, United States
• AMR Mobile- Site Number : 8400022 — Mobile, Alabama, United States
• Alliance for Multispeciality Research - Clinical Research Consortium- Site Number : 8400015 — Tempe, Arizona, United States
• AMR Miami- Site Number : 8400021 — Coral Gables, Florida, United States
• Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400003 — DeLand, Florida, United States
• Alliance for Multispeciality Research - Fort Myers- Site Number : 8400013 — Fort Myers, Florida, United States
• Accel Research Sites - Maitland- Site Number : 8400007 — Maitland, Florida, United States
• Innovation Medical Research Center - Palmetto Bay- Site Number : 8400011 — Palmetto Bay, Florida, United States
• Accel Research Site - NeuroStudies.net, LLC - ERN - PPDS- Site Number : 8400001 — Decatur, Georgia, United States
• AMR - Chicago- Site Number : 8400012 — Oak Brook, Illinois, United States
• Alliance for Multispeciality Research - Newton- Site Number : 8400020 — Newton, Kansas, United States
• Alliance for Multispeciality Research - Wichita East- Site Number : 8400014 — Wichita, Kansas, United States
• Alliance for Multispeciality Research - Lexington- Site Number : 8400018 — Lexington, Kentucky, United States
• Boston Clinical Trials- Site Number : 8400009 — Boston, Massachusetts, United States
• ActivMed Practices & Research- Site Number : 8400005 — Methuen, Massachusetts, United States
• Quest Research Institute- Site Number : 8400010 — Farmington Hills, Michigan, United States
• Alliance for Multispeciality Research - Kansas City- Site Number : 8400019 — Kansas City, Missouri, United States
• AMR Las Vegas - Site Number : 8400016 — Las Vegas, Nevada, United States
• Coastal Carolina Research Center - North Charleston- Site Number : 8400002 — North Charleston, South Carolina, United States
• Alliance for Multispeciality Research - Knoxville- Site Number : 8400017 — Knoxville, Tennessee, United States
• Charlottesville Medical Research- Site Number : 8400004 — Charlottesville, Virginia, United States
• Investigational Site Number : 0360001 — Botany, New South Wales, Australia
• Investigational Site Number : 0360003 — Bayswater, Victoria, Australia
• Investigational Site Number : 0360002 — Melbourne, Victoria, Australia

Full record on ClinicalTrials.gov

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