Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions

Recruiting now · Not applicable

Conditions studied: Ventricular Tachycardia

In brief

This is a research study that aims to understand if giving a lower dose of treatment all at once is as effective and safe as dividing it into three smaller doses for patients with a heart condition called refractory ventricular tachycardia (VT). These patients have not exhibited positive responses to conventional medications or procedures. This study aims to explore whether an alternative approach could yield more beneficial outcomes.

Key facts

Study ID

NCT06743789

Run by

Weill Medical College of Cornell University

People needed

40

Starts

2024-12-18

Expected to finish

2030-12-01

Last updated by the study team

2026-01-26

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Structural heart disease:
• Ischemic cardiomyopathy
• Non-ischemic cardiomyopathy
• Hypertrophic cardiomyopathy
• Refractory VT severity:
• VT leading to ICD shock with minimum 3 episodes in any 3-month period without reversible cause;
• Failed or intolerant to antiarrhythmic drug therapy (either amiodarone or ≥ 2 AADs) AND failed ablation (CA)
• OR ablation (CA) contraindicated
• Ability to understand study protocol and to write informed consent
• Willing to comply with specified pre-, post- and follow-up testing, evaluations and requirements
• Expected to remain available for at least 36 months after enrollment

You may not qualify if…

• Age < 18 years
• Pregnancy
• Prior chest radiation therapy

Where it is running

• Weill Cornell Medicine — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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