The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
Recruiting now · Not applicable
Conditions studied: Fasting, Immune Function, Glucose Tolerance
In brief
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.
Key facts
- Study ID
- NCT06737224
- Run by
- University of British Columbia
- People needed
- 15
- Starts
- 2025-01-10
- Expected to finish
- 2025-08-01
- Last updated by the study team
- 2025-03-07
Who can join
Age: 19 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged between 19 and 35 years.
- Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity).
You may not qualify if…
- History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease).
- Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks).
- Cigarette/vaping smoking.
- Physical limitation that will impair the ability of the participant to perform exercise.
- Individuals having a body mass index (BMI) over 30 kg/m2.
- Cancer diagnosis in the past 5 years.
- Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen).
- Being unable to read or communicate in English.
Where it is running
- University of British Columbia Okanagan Campus — Kelowna, British Columbia, Canada (enrolling)
Full record on ClinicalTrials.gov
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