Surgical Suction Aspirates Fluorescence Measurement

Recruiting now

Conditions studied: Gliomas, High-grade Glioma

In brief

Gliomas are tumors that occur in all ages; they include the most common malign primary central nervous system tumors in developed countries. Gliomas are often aggressive, and their recommended treatment is surgical resection and chemoradiation. Complete tumor removal is challenging because of diffuse cell growth and the proximity of functionally critical tissues. Surgeons use 5-aminolevulinic acid (5-ALA) drug-induced fluorescence to visually detect tumor cells, which improves resection rates and delays tumor progression. Tumor cells are often left unnoticed because of visual obstacles or weak fluorescence, which may lead to local recurrence and reoperations. Surgical suction devices are used to remove cancerous tissues, but so far the suction aspirate tissues have not been routinely used in tissue detection. This single-center observational study compares experts' visual detection of 5-ALA-induced fluorescence and fluorescence detected from the surgical suction waste. The fluorescence from the suction waste will not be reported back to the surgeon.

Key facts

Study ID

NCT06736470

Run by

Kuopio University Hospital

People needed

25

Starts

2023-02-07

Expected to finish

2026-01-01

Last updated by the study team

2024-12-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to neurosurgery department for surgical resection of a potential glioma
• Aged 18 years old or older
• Informed consent obtained

You may not qualify if…

• Patient belongs to the following vulnerable groups: children, pregnant, prisoners or intellectually disabled,,

Where it is running

• Kuopio University Hospital — Kuopio, Kuopio, Finland (enrolling)

Full record on ClinicalTrials.gov

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