Study of 225Ac-ABD147 to Establish Optimal Dose in Patients With SCLC and LCNEC of the Lung That Previously Received Platinum-based Chemotherapy
Running, not enrolling · Phase 1
Conditions studied: Small-Cell Lung Cancer (SCLC), Large Cell Neuroendocrine Carcinoma of the Lung
In brief
The study has 2 parts, Phase 1a and Phase 1b. The goal of Phase 1a is to gather safety, PK and initial efficacy data for 225Ac-ABD147 to better understand best doses for patients with small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) of the lung following platinum-based chemotherapy. An initial group of patients will also be given an experimental imaging agent called 111In-ABD147 to help understand where ABD147 goes in the body. The goal of Phase 1b is to gather additional safety and efficacy data on 225Ac-ABD147 to determine the best dose and to understand how those doses affect the same types of patients' cancers explored enrolled in Phase 1a.
Key facts
- Study ID
- NCT06736418
- Run by
- Abdera Therapeutics Inc.
- People needed
- 17
- Starts
- 2025-03-10
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-04-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Hoag Memorial Hospital Presbyterian — Newport Beach, California, United States
- University of California, San Francisco — San Francisco, California, United States
- University of California, Los Angeles — Santa Monica, California, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Sylvester Comprehensive Cancer Center, Univ of Miami — Miami, Florida, United States
- Florida Cancer Specialists - Sarasota — Sarasota, Florida, United States
- United Theranostics — Glen Burnie, Maryland, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- MD Anderson — Houston, Texas, United States
- Huntsman Cancer Institute — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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