Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

Recruiting now · Not applicable

Conditions studied: Obesity

In brief

The goal of this clinical trial is to investigate whether a Ketogenic Diet (KD) can increase Total Energy Expenditure (TEE), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.

Key facts

Study ID

NCT06736028

Run by

University of Alabama at Birmingham

People needed

20

Starts

2025-08-01

Expected to finish

2027-03-30

Last updated by the study team

2026-04-07

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI 30-45 kg/m2
• Both men and women
• Age between 18-65 years
• Sedentary to moderately active (<2 h/wk of moderate, structured, intentional, exercise)

You may not qualify if…

• Pregnancy or lactation
• Daily use of tobacco (>1 pk/wk)
• Change in weight greater than 5 lb in the previous 3 months
• Cognitive impairment
• Previous bariatric surgery
• History of eating disorder
• Presence of any condition (e.g. DM2, PCOS, inflammatory disease, untreated thyroid disease, fluid overload states such as chronic kidney disease, congestive heart failure, or cirrhosis)
• Use of any medication (e.g., glucocorticoid, GLP-1 analogues, hormone replacement therapy) deemed to interfere with study outcomes.
• Pre-menopausal women will need to have a regular menstrual cycle (28+/-2 days) or be on hormonal contraceptives
• Fasting glucose plasma concentration >125 mg/dl and/or HbA1c > 6.4%

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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