Effects of Mega-dose Vitamin D Pulse and Maintenance Therapy on Seizure Frequency, Fatigue, and Quality of Life: A Prospective Study

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Epilepsy

In brief

This prospective study aims to evaluate the effects of mega-dose vitamin D pulse therapy followed by maintenance therapy on seizure frequency, fatigue, and quality of life in patients with epilepsy. Participants will receive vitamin D supplementation, and clinical outcomes will be assessed over time to determine its potential benefits on seizure control and patient-reported outcomes.

Key facts

Study ID

NCT06736002

Run by

Chin-Wei Huang

People needed

200

Starts

2025-02-03

Expected to finish

2026-12-31

Last updated by the study team

2026-04-13

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 20 or above (inclusive)
• Diagnosed patients (refractory epilepsy refers to those who have used more than two drugs, and each drug has reached the When epileptic seizures cannot be well controlled at standard reasonable treatment doses, it is called refractory epilepsy)
• There is no imaging evidence of persistence or expansion of brain damage in the past three years
• Subjects or family members (caregivers) can comply with the trial plan and take vitamin D patients

Where it is running

• National Cheng Kung University Hospital — Tainan, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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