Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis
Running, not enrolling · Not applicable
Conditions studied: MASLD, Metabolic Dysfunction-Associated Steatotic Liver Disease
In brief
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Key facts
- Study ID
- NCT06735924
- Run by
- University of Alabama at Birmingham
- People needed
- 28
- Starts
- 2023-04-26
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age >18 years
- History of MASLD, with liver fat content > 5%
- Normal kidney function
- Stable medication for at least 1 month for diabetes mellitus if any
- Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits
You may not qualify if…
- Age < 18 years
- Inaccurate 24-hour urine collections
- Liver fat content <5%
- Liver cirrhosis
- Evidence of other chronic liver disease, viral hepatitis
- history of alcoholism within 2 years of enrollment
- Contra-indication to Magnetic Resonance Imaging
- Chronic kidney disease with estimated Glomerular Filtration rate < 60 ml/min/1.73m2
- Type 1 Diabetes Mellitus or treatment with insulin
- Uncontrolled diabetes
- Pregnancy, lactation or intention to be
- Uncontrolled hypertension
- Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID
- History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption
- Chronic fat malabsorption
- Use of immunosuppressive medications
- Known immuno-compromised status
- Active malignancy or treatment for malignanacy within the last 12 months
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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