Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

Recruiting now · Not applicable

Conditions studied: Hemodialysis, Cardioprotection

In brief

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Key facts

Study ID

NCT06735378

Run by

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

People needed

30

Starts

2025-01-20

Expected to finish

2025-12-31

Last updated by the study team

2025-01-22

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• must be on chronic hemodialysis for at least 3 months
• age 18 years or older
• willing and able to provide informed consent
• assessed to be safe and able to exercise by unit HD Nephrologist

You may not qualify if…

• regular vigorous exercise outside of hemodialysis
• over 79 years of age
• intradialytic exercise < 3 months
• poor echogenicity
• acute coronary syndrome in the past 3 months
• unstable arrhythmia/angina
• shortness of breath at rest or with minimal activity
• symptomatic hypoglycemia (>2x/week in the week prior to enrolment)

Where it is running

• London Health Sciences Centre — London, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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