Multicenter ALS Imaging Study

Recruiting now

Conditions studied: Amyotrophic Lateral Sclerosis, ALS

In brief

This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.

Key facts

Study ID

NCT06735014

Run by

University of Minnesota

People needed

90

Starts

2024-09-15

Expected to finish

2028-08-31

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Individuals will be excluded if they have any condition that makes MRI unsafe or if they are unable to comply with instructions.
• All participants will undergo a neurologic examination at enrollment. Control participants with clinically significant abnormal findings on neurological examination will be excluded from the study.

Where it is running

• University of Florida — Gainesville, Florida, United States (enrolling)
• Northwestern University — Evanston, Illinois, United States (enrolling)
• University of Minnesota — Minneapolis, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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