Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation

Recruiting now · Not applicable

Conditions studied: Rejection; Transplant, Liver

In brief

The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients. To this end, a panel of acute rejection indicator genes (both humoral and cell-mediated) will be selected from results published in the literature and applied to biological material derived from biopsies. The secodnary objective is to identify genes associated with the diagnosis of humoral acute rejection and those associated with the diagnosis of cell-mediated acute rejection.

Key facts

Study ID

NCT06734013

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

40

Starts

2024-10-17

Expected to finish

2025-06-01

Last updated by the study team

2024-12-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a diagnosis of post-OLT rejection prior to the visit at which they will be enrolled, with tissue available for RT-PCR investigations
• Age ≥ 18 years
• Informed consent

You may not qualify if…

• Age <18 years

Where it is running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (enrolling)

Full record on ClinicalTrials.gov

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