Transcranial Pulse Stimulation. a Potential Treatment for Early Dementia

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Alzheimer Disease

In brief

Alzheimer's Disease (AD) is characterized by the absence of treatments to slow, stop, or reverse its course, with patients finally losing cognitive functions, skills and independence. It is a chronic degenerative disease with high social and medical burden worldwide: AD ranked third among neurological disorders in terms of disability-adjusted life years (DALY) rates. The primary aim of the research protocol is to improve care for patients with AD, by implementing, with an innovative method, the currently available repertoire of neuromodulation techniques. For this aim, we will investigate whether Transcranial Pulse Stimulation (TPS) may induce cognitive improvement in patients with an early stage of dementia.

Key facts

Study ID

NCT06730438

Run by

Francesca Pistoia

People needed

100

Starts

2024-12-01

Expected to finish

2026-07-01

Last updated by the study team

2024-12-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age>18 years
• diagnosis of early dementia according to current international guidelines
• disease duration of at least 12 months
• consent to participate in the study.

You may not qualify if…

• medical instability interfering with standard neurological assessment
• any contraindication to preliminary MRI for MR-based real-time neuronavigation
• comorbidities which may interfere with cognitive status
• any contraindication to Transcranial Pulse Stimulation.

Where it is running

• San Salvatore Hospital — L’Aquila, Italy, Italy (enrolling)
• San Salvatore Hospital — L’Aquila, Italy, Italy (enrolling)

Full record on ClinicalTrials.gov

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