First-Line and Neoadjuvant Immunotherapy for Gastric Cancer
Recruiting now
Conditions studied: Advanced Gastric Cancer, Locally Advanced Gastric Carcinoma
In brief
This prospective observational study aims to evaluate the efficacy and safety of immune checkpoint inhibitors as first-line and neoadjuvant therapy for advanced gastric cancer, while also investigating relevant biomarkers to better understand their role in immunotherapy outcomes
Key facts
- Study ID
- NCT06727981
- Run by
- Qilu Hospital of Shandong University
- People needed
- 500
- Starts
- 2022-01-15
- Expected to finish
- 2028-01-15
- Last updated by the study team
- 2024-12-11
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years old or above
- Patients with advanced gastric cancer or locally advanced gastric cancer
- Have not received any previous anti-tumor therapy
- Patients expected to receive immunotherapy for first-line or neoadjuvant therapy
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
- Adequate organ function
You may not qualify if…
- Patients with contraindications to immunotherapy
- Have received anti-tumor treatments such as immunotherapy and chemotherapy
- Have a history of active immune deficiency or autoimmune diseases, including HIV positive test, or have other acquired or congenital immune deficiency diseases, or have a history of organ transplantation or autoimmune diseases
- Severe chronic or active infection requires systemic antibacterial, antifungal, or antiviral treatment, including tuberculosis infection. Have a history of active tuberculosis infection ≥ 1 year before recruitment should also be excluded, unless proved has been completed appropriate treatment
- History of allogeneic stem cell transplantation or organ transplantation
Where it is running
- Qilu Hospital of Shandong University — Jinan, Shandong, China (enrolling)
Full record on ClinicalTrials.gov
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